Literature summary extracted from

Storz, M.P.; Allegretta, G.; Kirsch, B.; Empting, M.; Hartmann, R.W.
From in vitro to in cellulo: structure-activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa (2014), Org. Biomol. Chem., 12, 6094-6104.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.3.1.230	(2-nitrophenyl)(thiophen-3-yl)methanol	inhibitor shows almost no time-dependency of PqsD inhibition	Pseudomonas aeruginosa
2.3.1.230	1-(2-nitrophenyl)propan-1-ol	best inhibitor in the cellular test	Pseudomonas aeruginosa

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.1.230	Pseudomonas aeruginosa	P20582	-	-

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
2.3.1.230	0.0011	-	pH not specified in the publication, temperature not specified in the publication	Pseudomonas aeruginosa	1-(2-nitrophenyl)propan-1-ol
2.3.1.230	0.0059	-	pH not specified in the publication, temperature not specified in the publication	Pseudomonas aeruginosa	(2-nitrophenyl)(thiophen-3-yl)methanol

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Release 2023.1 (January 2023)